Mastoparan 8 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps that activates Gi/o GPCRs. Mastoparan 8 is an analog of mastoparan with similar activity, including inducing mast cell degranulation and stimulating insulin secretion.
| Purity | ≥95% |
|---|---|
| Formula | C70H131N21O15 |
| Formula Wt. | 1506.96 |
| Synonym | Mas8 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | M0273 Info Sheet PDF |
|---|
dos Santos LD, Aparecido dos Santos Pinto JR, Menegasso AR, et al. Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP-III at the level of endosomal membranes from rat mast cells. Proteomics. 2012 Aug;12(17):2682-93. PMID: 22761183.
Cabrera MP, Alvares DS, Leite NB, et al. New insight into the mechanism of action of wasp mastoparan peptides: lytic activity and clustering observed with giant vesicles. Langmuir. 2011 Sep 6;27(17):10805-13. PMID: 21797216.
Etzerodt T, Henriksen JR, Rasmussen P, et al. Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. Biophys J. 2011 Jan 19;100(2):399-409. PMID: 21244836.
Todokoro Y, Yumen I, Fukushima K, et al. Structure of tightly membrane-bound mastoparan-X, a G-protein-activating peptide, determined by solid-state NMR. Biophys J. 2006 Aug 15;91(4):1368-79. PMID: 16714348.
Amin RH, Chen HQ, Veluthakal R, et al. Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteins. Endocrinology. 2003 Oct;144(10):4508-18. PMID: 12960065.
Armstead WM. Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury. Brain Res. 2003 May 9;971(2):153-60. PMID: 12706231.
Kowluru A. Identification and characterization of a novel protein histidine kinase in the islet beta cell: evidence for its regulation by mastoparan, an activator of G-proteins and insulin secretion. Biochem Pharmacol. 2002 Jun 15;63(12):2091-100. PMID: 12110368.
