Description
Mastoparan8isanantimicrobialpeptide(AMP)derivedfromthevenomofbeesandwaspsthatactivatesGi/oGPCRs.Mastoparan8isananalogofmastoparanwithsimilaractivity,includinginducingmastcelldegranulationandstimulatinginsulinsecretion.
Mastoparan8isanantimicrobialpeptide(AMP)derivedfromthevenomofbeesandwaspsthatactivatesGi/oGPCRs.Mastoparan8isananalogofmastoparanwithsimilaractivity,includinginducingmastcelldegranulationandstimulatinginsulinsecretion.
Purity | ≥95% |
---|---|
Formula | C70H131N21O15 |
FormulaWt. | 1506.96 |
Synonym | Mas8 |
StoreTemp | -20°C |
---|---|
ShipTemp | Ambient |
InfoSheet | M0273InfoSheetPDF |
---|
dosSantosLD,AparecidodosSantosPintoJR,MenegassoAR,etal.ProteomicprofilingofthemoleculartargetsofinteractionsofthemastoparanpeptideProtopolybiaMP-IIIatthelevelofendosomalmembranesfromratmastcells.Proteomics.2012Aug;12(17):2682-93.PMID:22761183.
CabreraMP,AlvaresDS,LeiteNB,etal.Newinsightintothemechanismofactionofwaspmastoparanpeptides:lyticactivityandclusteringobservedwithgiantvesicles.Langmuir.2011Sep6;27(17):10805-13.PMID:21797216.
EtzerodtT,HenriksenJR,RasmussenP,etal.Selectiveacylationenhancesmembranechargesensitivityoftheantimicrobialpeptidemastoparan-x.BiophysJ.2011Jan19;100(2):399-409.PMID:21244836.
TodokoroY,YumenI,FukushimaK,etal.Structureoftightlymembrane-boundmastoparan-X,aG-protein-activatingpeptide,determinedbysolid-stateNMR.BiophysJ.2006Aug15;91(4):1368-79.PMID:16714348.
AminRH,ChenHQ,VeluthakalR,etal.Mastoparan-inducedinsulinsecretionfrominsulin-secretingbetaTC3andINS-1cells:evidenceforitsregulationbyRhosubfamilyofGproteins.Endocrinology.2003Oct;144(10):4508-18.PMID:12960065.
ArmsteadWM.ProteinkinaseCactivationgeneratessuperoxideandcontributestoimpairmentofcerebrovasodilationinducedbyGproteinactivationafterbraininjury.BrainRes.2003May9;971(2):153-60.PMID:12706231.
KowluruA.Identificationandcharacterizationofanovelproteinhistidinekinaseintheisletbetacell:evidenceforitsregulationbymastoparan,anactivatorofG-proteinsandinsulinsecretion.BiochemPharmacol.2002Jun15;63(12):2091-100.PMID:12110368.