Mebendazole is a benzimidazole anti-parasitic/anti-helminthic compound that also exhibits anticancer chemotherapeutic activity. Mebendazole inhibits microtubule polymerization in parasitic worms. In melanoma cells, mebendazole decreases levels of Bcl-2 and induces apoptosis, suppressing cell growth. This compound also decreases Bcl-2 and XIAP levels in vivo, suppressing growth of melanoma xenografts.
| Cas No. | 31431-39-7 |
|---|---|
| Purity | ≥98% |
| Formula | C16H13N3O3 |
| Formula Wt. | 295.29 |
| Chemical Name | (5-Benzoyl-1H-benzimidazole-2-yl)carbamic acid methyl ester |
| IUPAC Name | methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate |
| Synonym | Mebendazol; Lomper; Noverme; Pantelmin |
| Melting Point | 288.5°C |
| Solubility | Soluble in formic acid. Practically insoluble in water, ethanol, ether and chloroform. |
| Appearance | Off white or yellowish powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | M1605 MSDS PDF |
|---|---|
| Info Sheet | M1605 Info Sheet PDF |
Doudican NA, Byron SA, Pollock PM, et al. XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. Anticancer Drugs. 2013 Feb;24(2):181-8. PMID: 23059386.
Doudican N, Rodriguez A, Osman I, et al. Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. Mol Cancer Res. 2008 Aug;6(8):1308-15. PMID: 18667591.
El-On J. Benzimidazole treatment of cystic echinococcosis. Acta Trop. 2003 Feb;85(2):243-52. PMID: 12606103.
