MonensinisapolyetherantibioticinitiallyproducedbyStreptomycesthatexhibitsantibactieralandanti-parasiticactivities.Monensiniscommerciallyusedincattlefeed;itactsasanionophore,transportingcationsacrosscellmembranes.Monensininhibitsautophagy,interferingwiththefusionoftheautophagosomeandthelysosome.
| CasNo. | 22373-78-0 |
|---|---|
| Purity | ≥98% |
| Formula | C36H61O11Na |
| FormulaWt. | 692.86 |
| ChemicalName | 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetra-hydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]-decane-7-butyricacidsodiumsalt |
| IUPACName | sodium;(2R,3S,4R)-4-[(2R,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2S,3R,5S)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate |
| Synonym | Monensinsodiumsalt;Coban;Romemsin;Rumensin |
| MeltingPoint | 267-269°C |
| Solubility | Slightlysolubleinwater.Solubleinorganicsolvents. |
| Appearance | AWhiteorAlmostWhiteCrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | M5753MSDSPDF |
|---|---|
| InfoSheet | M5753InfoSheetPDF |
ChoiHS,JeongEH,LeeTG,etal.AutophagyInhibitionwithMonensinEnhancesCellCycleArrestandApoptosisInducedbymTORorEpidermalGrowthFactorReceptorInhibitorsinLungCancerCells.TubercRespirDis(Seoul).2013Jul;75(1):9-17.PMID:23946753.
LavineMD,ArrizabalagaG.AnalysisofmonensinsensitivityinToxoplasmagondiirevealsautophagyasamechanismfordruginduceddeath.PLoSOne.2012;7(7):e42107.PMID:22848721.
