LKT/MOXIFLOXACIN FREE BASE/M5793/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/MOXIFLOXACIN FREE BASE/M5793/1 g

LKT/MOXIFLOXACIN FREE BASE/M5793/1 g

商品编号： M5793-1g

品牌： lktlabs

市场价： ¥12840.00

美元价： 7704.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDM5793

CasNo.151096-09-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Moxifloxacinisafluoroquinoloneantibioticcommonlyusedtotreatocularinfectionssuchasbacterialconjunctivitisaswellassinusandlunginfectionssuchaspneumonia.Moxifloxacindisplaysantibacterialefficacyagainstbothgramnegativeandgrampositivebacteria,preventingDNAsynthesisinbacterialpathogensbyinhibitingtopoisomeraseIVandbacterialDNAgyrase.ThiscompoundiscurrentlybeingexaminedasaconjunctivetherapywithanticanceragentsagainstseveralformsofcancerduetoitstopoisomeraseIIinhibition.Combiningmoxifloxacinwithanticanceragentsyieldsacytotoxicdrugsparingeffectduetothesynergismofthemechanismsofactionbetweenmoxifloxacinandtheanticancerdrugs.

ProductInfo

CasNo.	151096-09-2
Purity	≥98%
Formula	C₂₁H₂₄FN₃O₄
FormulaWt.	401.43
IUPACName	7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylicacid
Appearance	YellowSolid

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	M5793MSDSPDF
InfoSheet	M5793InfoSheetPDF

References

WohlkonigA,ChanPF,FosberryAP,etal.StructuralbasisofquinoloneinhibitionoftypeIIAtopoisomerasesandtarget-mediatedresistance.NatStructMolBiol.2010Sep;17(9):1152-3.PMID:20802486.

ReuveniD,HalperinD,ShalitI,etal.Moxifloxacinenhancesetoposide-inducedcytotoxic,apoptoticandanti-topoisomeraseIIeffectsinahumancoloncarcinomacellline.IntJOncol.2010Aug;37(2):463-71.PMID:20596674.

ReuveniD,HalperinD,FABIanI,etal.Moxifloxacinincreasesanti-tumorandanti-angiogenicactivityofirinotecaninhumanxenografttumors.BiochemPharmacol.2010Apr15;79(8):1100-7.PMID:20025849.

LaponogovI,SohiMK,VeselkovDA,etal.Structuralinsightintothequinolone-DNAcleavagecomplexoftypeIIAtopoisomerases.NatStructMolBiol.2009Jun;16(6):667-9.PMID:19448616.

StromanDW,DajcsJJ,CuppGA,etal.Invitroandinvivopotencyofmoxifloxacinandmoxifloxacinophthalmicsolution0.5%,anewtopicalfluoroquinolone.SurvOphthalmol.2005Nov;50Suppl1:S16-31.PMID:16257308.

AldredKJ,McPhersonSA,WangP,etal.DruginteractionswithBacillusanthracistopoisomeraseIV:biochemicalbasisforquinoloneactionandresistance.Biochemistry.2012Jan10;51(1):370-381.PMID:22126453.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂