Didyminisaflavonoidglycosidefoundincitrusfruitsthatdisplaysantioxidativeandanticancerchemotherapeuticactivities.Incellularandanimalmodelsofnon-smallcelllungcancer(NSCLC),didymininducesFas-mediatedapoptosisanddelaystumorgrowth.Additionally,didymindownregulatesPI3K,pAkt,Akt,andvimentinexpressionanddecreaseslevelsofCDK4,n-Myc,andcyclinsB1andD1invitro.Inanimalmodelsofneuroblastoma,didymindecreasestumorsize.
| CasNo. | 14259-47-3 |
|---|---|
| Purity | ≥98% |
| Formula | C28H34O14 |
| FormulaWt. | 594.56 |
| IUPACName | 5-hydroxy-2-(4-methoxyphenyl)-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one |
| Synonym | (S)-5,7-Dihydroxy-4′-methoxyflavanone-7-β-rutinosideIsosakuranetin |
| Solubility | MeOH |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D3215InfoSheetPDF |
|---|
SinghalJ,NagaprashanthaLD,VatsyayanR,etal.DidymininducesapoptosisbyinhibitingN-MycandupregulatingRKIPinneuroblastoma.CancerPrevRes(Phila).2012Mar;5(3):473-83.PMID:22174364.
HungJY,HsuYL,KoYC,etal.Didymin,adietaryflavonoidglycosidefromcitrusfruits,inducesFas-mediatedapoptoticpathwayinhumannon-small-celllungcancercellsinvitroandinvivo.LungCancer.2010Jun;68(3):366-74.PMID:19733932.
