Description
Peracetylated epigallocatechin-3-gallate (AcEGCG) is a close relative of epigallocatechin-3-gallate, a catechin found in green tea (Camellia sinensis). AcEGCG has a higher bioavailability than its parent compound and exhibits anti-inflammatory and anticancer chemotherapeutic activity in vitro and in vivo. AcEGCG activates ERK 1/2 signaling, inhibits acetylation of histone H3K9, and downregulates PI3K/Akt/NF-κB signaling to inhibit tumor growth in a variety of cancer-focused animal models.
References
Chiou YS, Sang S, Cheng KH, et al. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis. 2013 Jun;34(6):1315-22. PMID: 23385063.
Chiou YS, Ma NJ, Sang S, et al. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012 Apr 4;60(13):3441-51. PMID: 22409325.
Lambert JD, Sang S, Hong J, et al. Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate. Drug Metab Dispos. 2006 Dec;34(12):2111-6. PMID: 16997910.
