Peracetylatedepigallocatechin-3-gallate(AcEGCG)isacloserelativeofepigallocatechin-3-gallate,acatechinfoundingreentea(Camelliasinensis).AcEGCGhasahigherbioavailABIlitythanitsparentcompoundandexhibitsanti-inflammatoryandanticancerchemotherapeuticactivityinvitroandinvivo.AcEGCGactivatesERK1/2signaling,inhibitsacetylationofhistoneH3K9,anddownregulatesPI3K/Akt/NF-κBsignalingtoinhibittumorgrowthinavarietyofcancer-focusedanimalmodels.
| CasNo. | 148707-39-5 |
|---|---|
| Purity | ≥98% |
| Formula | C38H34O19 |
| FormulaWt. | 794.67 |
| IUPACName | 5,7-Diacetoxy-2-(3,4,5-triacetoxyphenyl)-3,4-dihydro-2H-chromen-3-yl3,4,5-triacetoxybenzoate |
| Synonym | PeracetylatedEpigallocatechingallate,OctaacetylEpigallocatechingallate |
| Appearance | WhiteCrystalPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E6236InfoSheetPDF |
|---|---|
| Brochures | GreenTeaFlyer |
| Brochures | NaturalProductsBooklet |
ChiouYS,SangS,ChengKH,etal.Peracetylated(-)-epigallocatechin-3-gallate(AcEGCG)potentlypreventsskincarcinogenesisbysuppressingthePKD1-dependentsignalingpathwayinCD34+skinstemcellsandskintumors.Carcinogenesis.2013Jun;34(6):1315-22.PMID:23385063.
ChiouYS,MaNJ,SangS,etal.Peracetylated(-)-epigallocatechin-3-gallate(AcEGCG)potentlysuppressesdextransulfatesodium-inducedcolitisandcolontumOrigenesisinmice.JAgricFoodChem.2012Apr4;60(13):3441-51.PMID:22409325.
LambertJD,SangS,HongJ,etal.Peracetylationasameansofenhancinginvitrobioactivityandbioavailabilityofepigallocatechin-3-gallate.DrugMetabDispos.2006Dec;34(12):2111-6.PMID:16997910.
