Description
Erucinisanisothiocyanate(ITC)andanalogofsulforaphanefoundincruciferousvegetables.Erucinexhibitsantioxidative,anti-inflammatory,neuroprotective,anticancerchemotherapeutic,andchemopreventiveactivities.LikeotherITCs,erucininducesphaseIIenzymes.Erucinalsoinhibitstelomeraseandcellularproliferationinhepatocellularcarcinomacells.Inanimalmodelsofbladdercancer,erucindecreasestumorweight.Inanimalandcellularmodelsofinflammation,erucindecreasesLPS-stimulatedexpressionofIL-6,IL-1β,TNF-α,iNOS,andCOX-2.Additionally,thiscompounddecreasesROSandneuronalapoptosisandincreaseslevelsofglutathione,preventing6-OHDA-inducedneurodegenerationincellularmodelsofParkinson’sdisease.
References
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