LKT/FISETIN/F3473/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/FISETIN/F3473/100 mg

LKT/FISETIN/F3473/100 mg

商品编号： F3473-100mg

品牌： lktlabs

市场价： ¥1100.00

美元价： 660.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDF3473

CasNo.528-48-3

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Fisetinisaflavonoidfoundinvariousplantsourcesthatexhibitsneuroprotective,cognitionenhancing,antioxidative,immunosuppressive,anti-angiogenic,andanticanceractivities.InanimalmodelsofAlzheimer’sdisease,fisetindecreaseslevelsofp25andincreasesphosphorylationofERK,resultinginfewerdeficitsinlearningandmemory.Incellularmodels,fisetindecreaseslevelsofH2O2-generatedsuperoxideanions,hydroxylrADIcals,andROS.Fisetinactivatessirtuins,displayinganti-agingpotential.Inanimalmodels,thiscompoundpreventsdelayed-typehypersensitivityreactions;inrelatedcellularmodels,fisetininhibitsTh1/Th4cytokineproduction,activationofNF-κB,andsignalingbynuclearfactorofactivatedTcells(NFAT).Invariouscelllines,fisetininhibitsmatrixmetalloproteinases1,3,7,9,and14,inhibitingtube/vesselformationandcellproliferation.Innasopharyngealcarcinomacells,fisetininhibitstheepithelial-to-mesenchymaltransition(EMT),preventingcellmigrationandinvasion.ThiscompoundalsoinhibitstopoisomerasesIandII.

ProductInfo

CasNo.	528-48-3
Purity	≥97%
Formula	C₁₅H₁₀O₆
FormulaWt.	286.24
IUPACName	2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
Synonym	3,3",4",7-Tetrahydroxyflavone
MeltingPoint	330°C
Appearance	Lightyellowpowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	F3473InfoSheetPDF

References

LiR,ZhaoY,ChenJ,etal.Fisetininhibitsmigration,invasionandepithelial-mesenchymaltransitionofLMP1-positivenasopharyngealcarcinomacells.MolMedRep.2014Feb;9(2):413-8.PMID:24297333.

CurraisA,PriorM,DarguschR,etal.Modulationofp25andinflammatorypathwaysbyfisetinmaintainscognitivefunctioninAlzheimer"sdiseasetransgenicmice.AgingCell.2013Dec17.[Epubaheadofprint].PMID:24341874.

ParkJH,JangYJ,ChoiYJ,etal.Fisetininhibitsmatrixmetalloproteinasesandreducestumorcellinvasivenessandendothelialcelltubeformation.NutrCancer.2013;65(8):1192-9.PMID:24099040.

SongB,GuanS,LuJ,etal.SuppressiveeffectsoffisetinonmiceTlymphocytesinvitroandinvivo.JSurgRes.2013Nov;185(1):399-409.PMID:23993202.

KangKA,PiaoMJ,KimKC,etal.Fisetinattenuateshydrogenperoxide-inducedcelldamagebyscavengingreactiveoxygenspeciesandactivatingprotectivefunctionsofcellularglutathionesystem.InVitroCellDevBiolAnim.2013Aug27.[Epubaheadofprint].PMID:23982916.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂