Description
GalantamineisanalkaloidoriginallyfoundinspeciesofGalanthus,Narcissus,Leucojum,andLycoris;itexhibitsneuroprotectiveandcognitionenhancingactivities.Galantamineinhibitsacetylcholinesterase(AChE)andactsasanallostericagoNISTonnicotinicacetylcholinereceptors(nAChRs)andmuscarinicacetylcholinereceptors(mAChRs);itissomewhatselectiveforα7nAChRs.GalantamineisclinicallyusedtoimprovecognitivedeficitsinsubjectswithAlzheimer’sdisease.GalantamineisneuroprotectiveandpromotesneurogenesisinanIGF-2-dependentmanner.GalantaminemayalsoinhibitP2X7receptors,increasingBcl-2expressionandinhibitingapoptosis.
References
KitaY,AgoY,HigashinoK,etal.GalantaminepromotesadulthippocampalneurogenesisviaM1muscarinicandα7nicotinicreceptorsinmice.IntJNeuropsychopharmacol.2014Dec;17(12):1957-68.PMID:24818616.
TsvetkovaD,ObreshkovaD,Zheleva-DimitrovaD,etal.Antioxidantactivityofgalantamineandsomeofitsderivatives.CurrMedChem.2013;20(36):4595-608.PMID:23834167.
AgoY,KodaK,TakumaK,etal.Pharmacologicalaspectsoftheacetylcholinesteraseinhibitorgalantamine.JPharmacolSci.2011;116(1):6-17.PMID:21498956.
Woodruff-PakDS,VogelRW3rd,WenkGL.Galantamine:effectonnicotinicreceptorbinding,acetylcholinesteraseinhibition,andlearning.ProcNatlAcadSciUSA.2001Feb13;98(4):2089-94.PMID:11172080.
