Description
Moniliformin is a mycotoxin initially produced by species of Fusarium that can be found in grain and vegetable products. Moniliformin may damage myocardial tissue as a result of decreasing glutathione peroxidase and reductase activities, preventing glutathione radical scavenging. Moniliformin also decreases collagen synthesis and upregulates expression of matrix metalloproteinases 1 and 13 (MMP1/13), inhibiting chondrocyte viability in vitro. In macrophages and dendritic cells, moniliformin alters CD surface marker expression and decreases endocytosis ability. Moniliformin may also inhibit pyruvate dehydrogenase.
References
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Ficheux AS, Sibiril Y, Parent-Massin D. Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: an in vitro study. Toxicon. 2013 Sep;71:1-10. PMID: 23685117.
von Bargen KW, Lohrey L, Cramer B, et al. Analysis of the Fusarium mycotoxin moniliformin in cereal samples using 13C2-moniliformin and high-resolution mass spectrometry. J Agric Food Chem. 2012 Apr 11;60(14):3586-91. PMID: 22428531.
Zhang A, Cao JL, Yang B, et al. Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease. J Zhejiang Univ Sci B. 2010 Mar;11(3):200-8. PMID: 20205306.
Chen LY, Tian XL, Yang B. A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin. Mycopathologia. 1990 May;110(2):119-24. PMID: 2366852.
Gathercole PS, Thiel PG, Hofmeyr JH. Inhibition of pyruvate dehydrogenase complex by moniliformin. Biochem J. 1986 Feb 1;233(3):719-23. PMID: 3707519.
