Description
MyriocinisderivedfromascomyceteIsariasinclairii.Myriocinistheparentcompoundoffingolimod,animmunosuppressivesphingosine-1receptorinhibitor.Myriocinexhibitsbothimmunosuppressiveandanticanceractivities.Thiscompoundinhibitsserinepalmitoyltransferase,preventingsphingolipidformation.Invitro,myriocindecreasesexpressionofcylinB1,cdc2,andcdc25Candincreaseexpressionofp53andp21,inducingG2/Mphasecellcyclearrestandinhibitinggrowthofmelanomacells.Inanimalmodels,myriocindecreaseslevelsofCD4+lymphocytesandaltersthetotallymphocytepopulations.
References
WadsworthJM,ClarkeDJ,McMahonSA,etal.Thechemicalbasisofserinepalmitoyltransferaseinhibitionbymyriocin.JAmChemSoc.2013Sep25;135(38):14276-85.PMID:23957439.
LeeYS,ChoiKM,ChoiMH,etal.SerinepalmitoyltransferaseinhibitormyriocininducesgrowthinhibitionofB16F10melanomacellsthroughG(2)/Mphasearrest.CellProlif.2011Aug;44(4):320-9.PMID:21645154.
ChibaK,MatsuyukiH,MaedaY,etal.Roleofsphingosine1-phosphatereceptortype1inlymphocyteegressfromsecondarylymphoidtissuesandthymus.CellMolImmunol.2006Feb;3(1):11-9.PMID:16549044.
JohnsonVJ,HeQ,OsuchowskiMF,etal.Disruptionofsphingolipidhomeostasisbymyriocin,amycotoxin,reducesthymicandsplenicT-lymphocytepopulations.Toxicology.2004Sep1;201(1-3):67-75.PMID:15297021.
