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LKT/N-ACETYL-S-(NU2032-PHENETHYLTHIOCARBAMOYL)-L-CYSTEINE/A0920/100 mg
ThiscompoundisanN-acetylcysteineconjugateofphenethylisothiocyanate(PEITC-NAC),exhibitinganticancerchemotherapeuticandchemopreventiveactivities.Inlungcancerandprostatecancermodels,PEITC-NACincreasesactivationofJNK,p53,andMAPKs,inducingapoptosis,decreasingtumorgrowth,andlimitingtumOrigenesis.
| Purity | ≥95% |
|---|---|
| Formula | C14H18N2O3S2 |
| FormulaWt. | 326.43 |
| ChemicalName | PhenethylisothiocyanateN-acetyl-L-cysteineconjugate;PEITCN-acetyl-L-cysteineconjugate |
| IUPACName | (2R)-2-acetamido-3-(2-phenylethylcarbamothioylsulfanyl)propanoicacid |
| Synonym | PEITC-NAC |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A0920InfoSheetPDF |
|---|
KassieF,MelkamuT,EndalewA,etal.Inhibitionoflungcarcinogenesisandcriticalcancer-relatedsignalingpathwaysbyN-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine,indole-3-carbinolandmyo-inositol,aloneandincombination.Carcinogenesis.2010Sep;31(9):1634-41.PMID:20603442.
YangYM,ConawayCC,ChiaoJW,etal.Inhibitionofbenzo(a)pyrene-inducedlungtumorigenesisinA/JmicebydietaryN-acetylcysteineconjugatesofbenzylandphenethylisothiocyanatesduringthepostinitiationphaseisassociatedwithactivationofmitogen-activatedproteinkinasesandp53activityandinductionofapoptosis.CancerRes.2002Jan1;62(1):2-7.PMID:11782348.
ChiaoJW,ChungF,KrzeminskiJ,etal.ModulationofgrowthofhumanprostatecancercellsbytheN-acetylcysteineconjugateofphenethylisothiocyanate.IntJOncol.2000Jun;16(6):1215-9.PMID:10811998.
