Butyric acid is a fatty acid found in many dairy products that exhibits anticancer activity. Butyric acid inhibits histone deacetylases (HDACs) and induces apoptosis and G1 phase cell cycle arrest in glioma cells. Additionally, butyric acid stimulates epithelial cell proliferation at low doses and inhibits proliferation at high doses.
| Cas No. | 107-92-6 |
|---|---|
| Purity | ≥98% |
| Formula | C4H8O2 |
| Formula Wt. | 88.10 |
| IUPAC Name | butanoic acid |
| Synonym | Butanoic acid; Butyric acid; Ethylacetic acid |
| Melting Point | -7°C |
| Solubility | Miscible with water, alcohol or ether. |
| Appearance | Colorless liquid |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | B8275 MSDS PDF |
|---|---|
| Info Sheet | B8275 Info Sheet PDF |
Kim SW, Hooker JM, Otto N, et al. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nucl Med Biol. 2013 Oct;40(7):912-8. PMID: 23906667.
Inagaki A, Sakata T. Dose-dependent stimulatory and inhibitory effects of luminal and serosal n-butyric acid on epithelial cell proliferation of pig distal colonic mucosa. J Nutr Sci Vitaminol (Tokyo). 2005 Jun;51(3):156-60. PMID: 16161765.
Komata T, Kanzawa T, Nashimoto T, et al. Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. Int J Oncol. 2005 May;26(5):1345-52. PMID: 15809727.
