LKT/NARINGIN/N0069/100 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/NARINGIN/N0069/100 g

LKT/NARINGIN/N0069/100 g

商品编号： N0069-100g

品牌： lktlabs

市场价： ¥2980.00

美元价： 1788.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDN0069

CasNo.10236-47-2

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Naringinisaphytoestrogenandflavanoneglycosideoriginallyfoundincitrusfruitsthatexhibitsanti-angiogenic,anticancerchemotherapeutic,antioxidative,neuroprotective,cognitionenhancing,nephroprotective,andanti-inflammatoryactivities.NaringininhibitsreleaseofVEGFinER+breastcancercells;insimilarcancermodels,naringinincreasesexpressionofp21anddecreasesexpressionofsurvivinandβ-catenin,suppressingcellandtumorgrowth.Thiscompoundbindsestrogenreceptors,actingasaselectiveestrogenreceptormodulator(SERM)inaconcentration-dependentmanner.Naringinalsoimprovescolchicine-induceddeficitsincognitiveperformanceandattenuatesoxidativedamagebydecreasinglevelsofmalondialdehydeandnitratesandincreasingactivityofsuperoxidedismutase,catalase,andglutathione-S-transferase.NaringinalsoimprovescognitivefunctionandCaMKIIactivityinanimalmodelsofAlzheimer’sdisease.Additionally,thiscompoundinhibitsgentamicin-inducedincreasesinTNF-α,IL-6,andNF-κBandsuppresseslevelsofBax,caspase3,andp53.

ProductInfo

CasNo.	10236-47-2
Purity	≥97%
Formula	C₂₇H₃₂O₁₄
FormulaWt.	580.53
ChemicalName	7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-gluco-pyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxy-phenyl)-4H-1-benzopyran-4-one
IUPACName	(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Synonym	Naringenin-7-rhamnoglucoside;Aurantiin
MeltingPoint	175-180°C
Solubility	Solubleinwater(1mg/ml),alcohol,acetone,andwarmaceticacid
Appearance	Almostwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	N0069InfoSheetPDF
Brochures	WNTBooklet

References

SahuBD,TatireddyS,KoneruM,etal.Naringinamelioratesgentamicin-inducednephrotoxicityandassociatedmitochondrialdysfunction,apoptosisandinflammationinrats:possIBLemechanismofnephroprotection.ToxicolApplPharmacol.2014May15;277(1):8-20.PMID:24637089.

LiH,YangB,HuangJ,etal.Naringininhibitsgrowthpotentialofhumantriple-negativebreastcancercellsbytargetingβ-cateninsignalingpathway.ToxicolLett.2013Jul18;220(3):219-28.PMID:23694763.

WangDM,YangYJ,ZhangL,etal.NaringinEnhancesCaMKIIActivityandImprovesLong-TermMemoryinaMouseModelofAlzheimer"sDisease.IntJMolSci.2013Mar11;14(3):5576-86.PMID:23478434.

GuoD,WangJ,WangX,etal.DoubledirectionaladjustingestrogeniceffectofnaringinfromRhizomadrynariae(Gusuibu).JEthnopharmacol.2011Nov18;138(2):451-7.PMID:21964193.

KumarA,DograS,PrakashA.Protectiveeffectofnaringin,acitrusflavonoid,againstcolchicine-inducedcognitivedysfunctionandoxidativedamageinrats.JMedFood.2010Aug;13(4):976-84.PMID:20673063.

SchindlerR,MentleinR.FlavonoidsandvitaminEreducethereleaseoftheangiogenicpeptidevascularendothelialgrowthfactorfromhumantumorcells.JNutr.2006Jun;136(6):1477-82.PMID:16702307.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂