Description
Naringin is a phytoestrogen and flavanone glycoside originally found in citrus fruits that exhibits anti-angiogenic, anticancer chemotherapeutic, antioxidative, neuroprotective, cognition enhancing, nephroprotective, and anti-inflammatory activities. Naringin inhibits release of VEGF in ER+ breast cancer cells; in similar cancer models, naringin increases expression of p21 and decreases expression of survivin and β-catenin, suppressing cell and tumor growth. This compound binds estrogen receptors, acting as a selective estrogen receptor modulator (SERM) in a concentration-dependent manner. Naringin also improves colchicine-induced deficits in cognitive performance and attenuates oxidative damage by decreasing levels of malondialdehyde and nitrates and increasing activity of superoxide dismutase, catalase, and glutathione-S-transferase. Naringin also improves cognitive function and CaMKII activity in animal models of Alzheimer’s disease. Additionally, this compound inhibits gentamicin-induced increases in TNF-α, IL-6, and NF-κB and suppresses levels of Bax, caspase 3, and p53.
References
Sahu BD, Tatireddy S, Koneru M, et al. Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol. 2014 May 15;277(1):8-20. PMID: 24637089.
Li H, Yang B, Huang J, et al. Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. Toxicol Lett. 2013 Jul 18;220(3):219-28. PMID: 23694763.
Wang DM, Yang YJ, Zhang L, et al. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2013 Mar 11;14(3):5576-86. PMID: 23478434.
Guo D, Wang J, Wang X, et al. Double directional adjusting estrogenic effect of naringin from Rhizoma drynariae (Gusuibu). J Ethnopharmacol. 2011 Nov 18;138(2):451-7. PMID: 21964193.
Kumar A, Dogra S, Prakash A. Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. J Med Food. 2010 Aug;13(4):976-84. PMID: 20673063.
Schindler R, Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J Nutr. 2006 Jun;136(6):1477-82. PMID: 16702307.
