LoganinisaniridoidglucosidefoundintheCornusofficialisplant.Loganindisplaysanti-inflammatory,antioxidative,cognitionenhancing,andneuroprotectiveactivities.Loganininhibitsβ-secretaseinvitroandincreasesperformanceinMorriswatermazeandY-mazetestsinvivo,suggestingpotentialbenefitinmemoryimpairmentandAlzheimer’sdisease.ThiscompoundalsomodulatesERKsignalingtodecreaseconnectivetissuegrowthfactoranddownregulatesexpressionofMCP-1,NF-κB,andiNOSinanimalmodels.
| CasNo. | 18524-94-2 |
|---|---|
| Purity | ≥98% |
| Formula | C17H26O10 |
| FormulaWt. | 390.38 |
| ChemicalName | Methyl(1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate |
| IUPACName | methyl(1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate |
| Synonym | 7-Hydroxy-6-desoxyverbenalin;(1S,4aS,6S,7R,7aS)-6-Hydroxy-1-((1S,4R,5S)-5-hydroxy-4-(S)-hydroxy-3-(R)-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-methyl-1,4a,5,6,7,7a-hexahydro-cyclopenta[c]pyran-4-carboxylicacidmethylester |
| MeltingPoint | 222°C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | L5624MSDSPDF |
|---|---|
| InfoSheet | L5624InfoSheetPDF |
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JiangWL,ZhangSP,HouJ,etal.Effectofloganinonexperimentaldiabeticnephropathy.Phytomedicine.2012Feb15;19(3-4):217-22.PMID:21978885.
ParkCH,TanakaT,KimJH,etal.Hepato-protectiveeffectsofloganin,iridoidglycosidefromCorniFructus,againsthyperglycemia-activatedsignalingpathwayinliveroftype2diabeticdb/dbmice.Toxicology.2011Nov28;290(1):14-21.PMID:21864639.
KwonSH,KimHC,LeeSY,etal.Loganinimproveslearningandmemoryimpairmentsinducedbyscopolamineinmice.EurJPharmacol.2009Oct1;619(1-3):44-9.PMID:19666019.
