MicrocystinRRisacyclicheptapeptideinitiallyproducedbyspeciesofcyanobacteriaMicrocystis.MicrocystinRRexhibitscytotoxic,pro-oxidative,andcarcinogenicproperties.MicrocystinRRinducesendocrinedisruptionandalterscholesterolsynthesisandlipidoxidationinvivo.Additionally,MicrocystinRRinducesmitochondrialdysfunctionandoxidativestress,alteringgonadalstructureindevelopment.Inotheranimalmodels,MicrocystinRRalterslevelsofBcl-2,Bax,p53,andGRP78,inducingapoptosisandliverdamage.
| CasNo. | 111755-37-4 |
|---|---|
| Purity | ≥95% |
| Formula | C49H75N13O12 |
| FormulaWt. | 1038.20 |
| IUPACName | (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylicacid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | BlueIce |
| MSDS | M3407MSDSPDF |
|---|---|
| InfoSheet | M3407InfoSheetPDF |
PavagadhiS,NateraS,RoessnerU,etal.InsightsintoLipidomicPerturbationsinZebrafishTissuesuponExposuretoMicrocystin-LRandMicrocystin-RR.EnvironSciTechnol.2013Dec17;47(24):14376-84.PMID:24152164.
ZhaoS,XieP,LiG,etal.Theproteomicstudyoncellularresponsesofthetestesofzebrafish(Daniorerio)exposedtomicrocystin-RR.Proteomics.2012Jan;12(2):300-12.PMID:22140076.
HuangP,ZhengQ,XuLH.TheapoptoticeffectoforaladmiNISTrationofmicrocystin-RRonmiceliver.EnvironToxicol.2011Oct;26(5):443-52.PMID:20196164.
