Description
DimebonisanactivatorofAMPK,apotentiatorofAMPA,andaninhibitorofL-typevoltage-gatedCa2+channels,NMDAreceptors,H1/2histaminereceptors,α-adrenergicreceptors,and5-HT2C/5A/6receptors.Dimebondisplaysneuroprotectiveandcognitionenhancingeffectsinneurodegenerativediseases.DimebondecreasesneuronalexcitABIlityandglutamaterelease.Inanimalmodelsofautotrophiclateralsclerosis(ALS),dimebondelaystheonsetofsymptomsandincreasestheLifespan.InanimalmodelsofAlzheimer’sdisease,thiscompoundregulatesAPPmetabolism,decreasinglevelsofamyloid-β(Aβ).Inotheranimalmodels,dimebonpreventsAβ-inducedmitochondrialswellinginthebrain.DimebonalsoexhibitsbeneficialeffectsinanimalmodelsofParkinson’sdisease.
References
CoughlanKS,MitchemMR,HoggMC,etal."Preconditioning"withlatrepirdine,anadenosine5"-monophosphate-activatedproteinkinaseactivator,delaysamyotrophiclateralsclerosisprogressioninSOD1(G93A)mice.NeurobiolAging.2015Feb;36(2):1140-50.PMID:25443289.
ShevtsovaEF,VinogradovaDV,KireevaEG,etal.DimebonattenuatestheAβ-inducedmitochondrialpermeabilization.CurrAlzheimerRes.2014;11(5):422-9.PMID:24801220.
WeisováP,AlvarezSP,KilbrideSM,etal.LatrepirdineisapotentactivatorofAMP-activatedproteinkinaseandreducesneuronalexcitability.TranslPsychiatry.2013Oct22;3:e317.PMID:24150226.
SteeleJW,GandyS.Latrepirdine(Dimebon®),apotentialAlzheimertherapeutic,regulatesautophagyandneuropathologyinanAlzheimermousemodel.Autophagy.2013Apr;9(4):617-8.PMID:23380933.
WuJ,LiQ,BezprozvannyI.EvaluationofDimebonincellularmodelofHuntington"sdisease.MolNeurodegener.2008Oct21;3:15.PMID:18939977.
GrigorevVV,DranyiOA,BachurinSO.ComparativestudyofactionmechanismsofdimebonandmemantineonAMPA-andNMDA-subtypesglutamatereceptorsinratcerebralneurons.BullExpBiolMed.2003Nov;136(5):474-7.PMID:14968164.
