DU-14inhibitssteroidsulfatase,displayingneuromodulatory,anti-amnestic,andcognitionenhancingactivities.DU-14inhibitstheamnesticeffectsofscopolamine,likelyenhancingcognitivefunctionthroughincreasinglevelsofexcitatoryneurosteroids.Inrats,DU-14enhancesmemoryacquisitionandlearningassociatedwithcontextualfearandspatialmemory,butmayimpairmemoryacquisitioninanimalswithhippocampallesions.
| CasNo. | 186303-55-9 |
|---|---|
| Purity | ≥98% |
| Formula | C22H38N2O4S |
| FormulaWt. | 426.6 |
| ChemicalName | (p-O-sulfamoyl)-N-tetradecanoyltyramine |
| IUPACName | [4-[2-(tetradecanoylamino)ethyl]phenyl]sulfamate |
| Solubility | DMSO(25mg/ml) |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D8014InfoSheetPDF |
|---|
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JohnsonDA,WuT,LiP,etal.Theeffectofsteroidsulfataseinhibitiononlearningandspatialmemory.BrainRes.2000May26;865(2):286-90.PMID:10821934.
JohnsonDA,RhodesME,BoniRL,etal.Chronicsteroidsulfataseinhibitionby(p-O-sulfamoyl)-N-tetradecanoyltyramineincreasesdehydroepiandrosteronesulfateinwholebrain.LifeSci.1997;61(24):PL355-9.PMID:9399636.
