Ebastineisasecond-generationantihistamineandanti-inflammatorycompoundthatisclinicallyusedtotreatallergicrhinitis.Likeothernewerantihistamines,admiNISTrationofebastineresultsinlessofasedativeeffectthanearlyantihistamines.EbastinealsoincreasesproductionofIFN-γ.ThiscompoundactsasanantagonistathistamineH1receptors.
| CasNo. | 90729-43-4 |
|---|---|
| Purity | ≥98% |
| Formula | C32H39NO2 |
| FormulaWt. | 469.66 |
| IUPACName | 4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one |
| MeltingPoint | 80-86°C |
| Appearance | WhitetoOff-WhiteFinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | E0403MSDSPDF |
|---|---|
| InfoSheet | E0403InfoSheetPDF |
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CiprandiG,CirilloI,PistorioA,etal.EbastineincreasesIFN-gammaproductioninpatientswithpersistentallergicrhinitis.JBiolRegulHomeostAgents.2009Jan-Mar;23(1):31-6.PMID:19321044.
TagawaM,KanoM,OkamuraN,etal.NeuroimagingofhistamineH1-receptoroccupancyinhumanbrainbypositronemissiontomography(PET):acomparativestudyofebastine,asecond-generationantihistamine,and(+)-chlorpheniramine,aclassicalantihistamine.BrJClinPharmacol.2001Nov;52(5):501-9.PMID:11736858.
