Eletriptan is a neuromodulator that acts an agonist at 5-HT1B/1D receptors and has selectivity for cranial arteries. Eletriptan is commonly used to treat acute migraines. Eletriptan inhibits activation of the trigeminovascular system, preventing nausea and emesis in vivo. Additionally, eletriptan may induce vasoconstriction of thoracic blood vessels, causing chest symptoms after administration.
| Cas No. | 143322-58-1 |
|---|---|
| Purity | ≥90% |
| Formula | C22H26N2O2S |
| Formula Wt. | 382.52 |
| Chemical Name | 3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-5-(2-phenylsulfonylethyl)-1H-indole |
| IUPAC Name | 5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole |
| Appearance | Yellowish Oil |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | E4419 Info Sheet PDF |
|---|
Almas M, Tepper SJ, Landy S, et al. Consistency of eletriptan in treating migraine: Results of a randomized, within-patient multiple-dose study. Cephalalgia. 2013 Dec 19. [Epub ahead of print]. PMID: 23946318.
Sandrini G, Perrotta A, Tassorelli C, et al. Eletriptan. Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1587-98. PMID: 19929447.
Wackenfors A, Jarvius M, Ingemansson R, et al. Triptans induce vasoconstriction of human arteries and veins from the thoracic wall. J Cardiovasc Pharmacol. 2005 May;45(5):476-84. PMID: 15821444.
Hoskin KL, Lambert GA, Donaldson C, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res. 2004 Feb 13;998(1):91-9. PMID: 14725972.
