EletriptanisaneuromodulatorthatactsanagoNISTat5-HT1B/1Dreceptorsandhasselectivityforcranialarteries.Eletriptaniscommonlyusedtotreatacutemigraines.Eletriptaninhibitsactivationofthetrigeminovascularsystem,preventingnauseaandemesisinvivo.Additionally,eletriptanmayinducevasoconstrictionofthoracicbloodvessels,causingchestsymptomsafteradministration.
| CasNo. | 143322-58-1 |
|---|---|
| Purity | ≥90% |
| Formula | C22H26N2O2S |
| FormulaWt. | 382.52 |
| ChemicalName | 3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-5-(2-phenylsulfonylethyl)-1H-indole |
| IUPACName | 5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole |
| Appearance | YellowishOil |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E4419InfoSheetPDF |
|---|
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WackenforsA,JarviusM,IngemanssonR,etal.Triptansinducevasoconstrictionofhumanarteriesandveinsfromthethoracicwall.JCardiovascPharmacol.2005May;45(5):476-84.PMID:15821444.
HoskinKL,LambertGA,DonaldsonC,etal.The5-hydroxytryptamine1B/1D/1Freceptoragonistseletriptanandnaratriptaninhibittrigeminovascularinputtothenucleustractussolitariusinthecat.BrainRes.2004Feb13;998(1):91-9.PMID:14725972.
