Entacaponeisaninhibitorofcatechol-O-methyltransferase(COMT),anenzymeresponsIBLeformetabolismofdopamine.EntacaponeiscommonlyusedtotreatParkinson’sdiseaseandisgivenwithL-DOPAasitreducesclearanceofL-DOPAandimprovesmotorfunction.Entacaponealsodisplaysotherneuroprotectivebenefit,particularlyinmodelsofAlzheimer’sdisease;itpreventsα-synucleinandamyloid-β(Aβ)oligomerizationandfibrilformation.Thiscompounddecreasesstriatalhomovanillicacidlevels.
| CasNo. | 116314-67-1 |
|---|---|
| Purity | ≥98% |
| Formula | C14H15N3O5 |
| FormulaWt. | 305.29 |
| ChemicalName | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide |
| IUPACName | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide |
| Appearance | Lightyelloworyellowcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | E5575MSDSPDF |
|---|---|
| InfoSheet | E5575InfoSheetPDF |
DiGiovanniS,EleuteriS,PaleologouKE,etal.Entacaponeandtolcapone,twocatecholO-methyltransferaseinhibitors,blockfibrilformationofalpha-synucleinandbeta-amyloidandprotectagainstamyloid-inducedtoxicity.JBiolChem.2010May14;285(20):14941-54.PMID:20150427.
HamaueN,OgataA,TeradoM,etal.Entacapone,acatechol-O-methyltransferaseinhibitor,improvesthemotoractivityanddopaminecontentofbasalgangliainaratmodelofParkinson"sdiseaseinducedbyJapaneseencephalitisvirus.BrainRes.2010Jan14;1309:110-5.PMID:19879254.
DeleuD,NorthwayMG,HanssensY.ClinicalpharmacokineticandpharmacodynamicpropertiesofdrugsusedinthetreatmentofParkinson"sdisease.ClinPharmacokinet.2002;41(4):261-309.PMID:11978145.
TörnwallM,TuomainenP,MänNISTöPT.ModulationofratbrainendogenousdopaminemetabolismbynewinhibitorsofcatecholO-methyltransferase.EurJPharmacol.1993Aug3;239(1-3):39-45.PMID:8223912.
