Epothiloneisananticancerchemotherapeuticthatactsasananti-mitoticcompound;itbindsthetaxanepocketofβ-tubulin,usingsidechainstoinduceformationofashorthelixandpreventingmicrotubuledepolymerization.EpothilonedisplaysactivityagainstlungcancerandprostatecancerinclinicaltrialsandmayshowbenefitintreatmentofneurodegenerativediseasessuchasAlzheimer’sdisease.Typically,thedegreeofchemotherapeuticactivityofthethreeepothilonesubtypesfollowsthealphabet,whereEpoA>EpoB>EpoD.
| CasNo. | 152044-53-6 |
|---|---|
| Purity | ≥95% |
| Formula | C26H39NO6S |
| FormulaWt. | 493.66 |
| IUPACName | (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxABIcyclo[14.1.0]heptadecane-8,12-dione |
| Solubility | SolubleinDMSO(≥99mg/mL)andEthanol(≥99mg/mL).PracticallyinsolubleinWater(<1mg> |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E6256MSDSPDF |
|---|---|
| InfoSheet | E6256InfoSheetPDF |
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