LKT/EPOTHILONE B/E6257/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/EPOTHILONE B/E6257/5 mg

LKT/EPOTHILONE B/E6257/5 mg

商品编号： E6257-5mg

品牌： lktlabs

市场价： ¥3600.00

美元价： 2160.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE6257

CasNo.152044-54-7

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Epothiloneisananticancerchemotherapeuticandneuroprotectivecompoundthatactsasanantimitoticcompound;itbindsthetaxanepocketofβ-tubulin,usingsidechainstoinduceformationofashorthelixandpreventingmicrotubuledepolymerization.EpothilonedisplaysactivityagainstlungcancerandprostatecancerinclinicaltrialsandmayshowbenefitintreatmentofneurodegenerativediseasessuchasAlzheimer’sdisease.Additionally,epothiloneBinhibitsglioblastomacellmigration.Inanimalmodelsofspinalcordinjury,epothiloneBdecreasesscarring,stimulatesaxonalregeneration,andimprovesmotordeficits.Typically,thedegreeofchemotherapeuticactivityofthethreeepothilonesubtypesfollowsthealphabet,whereEpoA>EpoB>EpoD.

ProductInfo

CasNo.	152044-54-7
Purity	≥98%
Formula	C₂₇H₄₁NO₆S
FormulaWt.	507.68
IUPACName	(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxABIcyclo[14.1.0]heptadecane-5,9-dione
Solubility	SolubleinDMSO(≥102mg/mL)andEthanol(≥102mg/mL).PracticallyinsolubleinWater(<1mg>
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	E6257InfoSheetPDF

References

RuschelJ,HellalF,FlynnKC,etal.SystemicadmiNISTrationofepothiloneBpromotesaxonregenerationafterspinalcordinjury.Science.2015Mar12.[Epubaheadofprint].PMID:25765066.

ProtaAE,BargstenK,ZurwerraD,etal.Molecularmechanismofactionofmicrotubule-stabilizinganticanceragents.Science.2013Feb1;339(6119):587-90.PMID:23287720.

EntwistleRA,RizkRS,ChengDM,etal.Differentiatingbetweenmodelsofepothilonebindingtomicrotubulesusingtubulinmutagenesis,cytotoxicity,andmolecularmodeling.ChemMedChem.2012Sep;7(9):1580-6.PMID:22807375.

PaganoA,HonoréS,MohanR,etal.EpothiloneBinhibitsmigrationofglioblastomacellsbyinducingmicrotubulecatastrophesandaffectingEB1accumulationatmicrotubuleplusends.BiochemPharmacol.2012Aug15;84(4):432-43.PMID:22634050.

EdelmanMJ,ShvartsbeynM.Epothilonesindevelopmentfornon--small-celllungcancer:novelanti-tubulinagentswiththepotentialtoovercometaxaneresistance.ClinLungCancer.2012May;13(3):171-80.PMID:22133291

KellyWK.Epothilonesinprostatecancer.UrolOncol.2011Jul-Aug;29(4):358-65.PMID:19914096.

Khrapunovich-BaineM,MenonV,YangCP,etal.Hallmarksofmolecularactionofmicrotubulestabilizingagents:effectsofepothiloneB,ixabepilone,pelorusideA,andlaulimalideonmicrotubuleconformation.JBiolChem.2011Apr1;286(13):11765-78.PMID:21245138.

LeeJJ,KellyWK.Epothilones:tubulinpolymerizationasanoveltargetforprostatecancertherapy.NatClinPractOncol.2009Feb;6(2):85-92.PMID:19048010.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂