Epothiloneisananticancerchemotherapeuticthatactsasananti-mitoticcompound;itbindsthetaxanepocketofβ-tubulin,usingsidechainstoinduceformationofashorthelixandpreventingmicrotubuledepolymerization.EpothilonedisplaysactivityagainstlungcancerandprostatecancerinclinicaltrialsandmayshowbenefitintreatmentofneurodegenerativediseasessuchasAlzheimer’sdisease.Typically,thedegreeofchemotherapeuticactivityofthethreeepothilonesubtypesfollowsthealphabet,whereEpoA>EpoB>EpoD.
| CasNo. | 189453-10-9 |
|---|---|
| Purity | ≥98% |
| Formula | C27H41NO5S |
| FormulaWt. | 491.68 |
| IUPACName | (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E6356MSDSPDF |
|---|---|
| InfoSheet | E6356InfoSheetPDF |
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