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当前位置: 首页 > 产品中心 > clinical_research > LKT/ESCITALOPRAM OXALATE/E7209/100 mg
商品详细LKT/ESCITALOPRAM OXALATE/E7209/100 mg
LKT/ESCITALOPRAM OXALATE/E7209/100 mg
LKT/ESCITALOPRAM OXALATE/E7209/100 mg
商品编号: E7209-100mg
品牌: lktlabs
市场价: ¥4480.00
美元价: 2688.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Escitalopram is the S-enantiomer of racemic citalopram; like citalopram, this compound is an SSRI that exhibits antidepressant and anxiolytic qualities and is also effective in treating OCD. Escitalopram inhibits the serotonin transporter (SERT), preventing reuptake of serotonin. Escitalopram may have other potential uses, as it decreased weight in a study of obese subjects with binge eating disorder and displayed anti-inflammatory activity through inhibition of NO and TNF-α production. This compound is associated with prolongation of the cardiac QT interval and may inhibit osteoblast and osteoclast formation as well.

Product Info

Cas No.

219861-08-2

Purity

≥99%

Formula

C22H21FN2O • C2H2O4

Formula Wt.

414.43

IUPAC Name

(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid

Melting Point

152-153°C

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7209 MSDS PDF

Info Sheet

E7209 Info Sheet PDF

References

Hodge JM, Wang Y, Berk M, et al. Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry. 2013 Jul 1;74(1):32-9. PMID: 23260229.

Tynan RJ, Weidenhofer J, Hinwood M, et al. A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain Behav Immun. 2012 Mar;26(3):469-79. PMID: 22251606.

Zhong H, Haddjeri N, Sánchez C. Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter--a review of current understanding of its mechanism of action. Psychopharmacology (Berl). 2012 Jan;219(1):1-13. PMID: 21901317.

van Gorp F, Whyte IM, Isbister GK. Clinical and ECG effects of escitalopram overdose. Ann Emerg Med. 2009 Sep;54(3):404-8. PMID: 19556032.

Stein DJ, Andersen EW, Tonnoir B, et al. Escitalopram in obsessive-compulsive disorder: a randomized, placebo-controlled, paroxetine-referenced, fixed-dose, 24-week study. Curr Med Res Opin. 2007 Apr;23(4):701-11. PMID: 17407626.

Kasper S, Stein DJ, Loft H, et al. Escitalopram in the treatment of social anxiety disorder: randomised, placebo-controlled, flexible-dosage study. Br J Psychiatry. 2005 Mar;186:222-6. PMID: 15738503.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂