Description
Etodolacisanon-steroidalanti-inflammatorydrug(NSAID)thatinhibitsCOX-2;someofitsantinociceptiveandanalgesicactivitiesstemsfromitsABIlitytoalsoactivateanddesensitizetransientreceptorpotentialankyrin1(TRPA1)channels.Etodolacalsoexhibitsanticancerandchemopreventiveactivities,decreasingincidenceofintraductalpapillarycarcinomainvivo.Etodolacinducescellcyclearrestandinhibitsgrowthinhepatocellularcarcinomacells,increasingexpressionofp21andp27anddecreasingexpressionofCDK2,CDK4,Cdc2,cyclinA,andcyclinB1.EtodolacalsodisplaysrADIcalscavengingactivityinvitro.
References
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AdachiT,TajimaY,KurokiT,etal.Chemopreventiveeffectsofaselectivecyclooxygenase-2inhibitor(etodolac)onchemicallyinducedintraductalpapillarycarcinomaofthepancreasinhamsters.Carcinogenesis.2008Apr;29(4):830-3.PMID:18296437.
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ChengJ,ImanishiH,LiuW,etal.InvolvementofcellcycleregulatoryproteinsandMAPkinasesignalingpathwayingrowthinhibitionandcellcyclearrestbyaselectivecyclooxygenase2inhibitor,etodolac,inhumanhepatocellularcarcinomacelllines.CancerSci.2004Aug;95(8):666-73.PMID:15298730.
