EtomidateactivatesGABA-Areceptors,displayingneuromodulatory,anesthetic,andamnesticactivities.EtomidatepreventsneurotransmitterreleaseinneuronsbyinhibitingpresynapticexcitatorysynaptictransmissioninaSNARE-dependentmanner.Etomidatealsoattenuatesacetylcholine-inducedrelaxationinaorticendothelialtissue,butdoesnotdisplaysignificantcardiovascularsideeffectswhenusedclinically.Inanimalmodels,etomidateimpairsmemoryperformanceinseveraltasks.
| CasNo. | 33125-97-2 |
|---|---|
| Purity | ≥98% |
| Formula | C14H16N2O2 |
| FormulaWt. | 244.29 |
| IUPACName | ethyl3-[(1R)-1-phenylethyl]imidazole-4-carboxylate |
| Synonym | Amidate |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E7758InfoSheetPDF |
|---|
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SohnJT,KimHJ,ChoHC,etal.Effectofetomidateonendothelium-dependentrelaxationinducedbyacetylcholineinrataorta.AnaesthIntensiveCare.2004Aug;32(4):476-81.PMID:15682522.
