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商品详细LKT/ETORICOXIB/E7858/5 mg
LKT/ETORICOXIB/E7858/5 mg
LKT/ETORICOXIB/E7858/5 mg
商品编号: E7858-5mg
品牌: lktlabs
市场价: ¥1100.00
美元价: 660.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antioxidative, anticancer, anti-angiogenic, and chemopreventive activities. Etoricoxib inhibits COX-2; it also increases activity of superoxide dismutase, catalase, glutathione reductase, and glutathione transferase in animal models. Etoricoxib downregulates expression of matrix metalloproteinases 2 and 9 (MMP2/9), COX-2, MPC-1, VEGF, and MIP-1β in vivo. In other animal models, etoricoxib decreases aberrant crypt foci and lesion formation, suppressing colon carcinogenesis.

Product Info

Cas No.

202409-33-4

Purity

≥99%

Formula

C18H15ClN2O2S

Formula Wt.

358.84

IUPAC Name

5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7858 MSDS PDF

Info Sheet

E7858 Info Sheet PDF

Brochures

NSAID Flyer

References

Nadda N, Vaish V, Setia S, et al. Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer. Biomed Pharmacother. 2012 Sep;66(6):474-83. PMID: 22681911.

Sharma P, Kaur J, Sanyal SN. Effect of etoricoxib, a cyclooxygenase-2 selective inhibitor on aberrant crypt formation and apoptosis in 1,2 dimethyl hydrazine induced colon carcinogenesis in rat model. Nutr Hosp. 2010 Jan-Feb;25(1):39-48. PMID: 20204254.

Kanwar SS, Vaiphei K, Nehru B, et al. Antioxidative effects of nonsteroidal anti-inflammatory drugs during the initiation stages of experimental colon carcinogenesis in rats. J Environ Pathol Toxicol Oncol. 2008;27(2):89-100. PMID: 18540845.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂