Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2; it exhibits anti-inflammatory, analgesic, and antioxidative activities. Fenbufen is clinically used to treat rheumatoid arthritis, tendinitis, and ankylosing spondylitis. In vitro, fenbufen scavenges O2 radicals and ROS.
| Cas No. | 36330-85-5 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14O3 |
| Formula Wt. | 254.28 |
| Chemical Name | γ-Oxo-[1,1'-biphenyl]-4-butanoic acid |
| IUPAC Name | 4-oxo-4-(4-phenylphenyl)butanoic acid |
| Synonym | Bufemid; Cinopol; Lederfen |
| Melting Point | 185-187°C |
| Solubility | Soluble in dimethyl sulfoxide. |
| Appearance | White or Almost White Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | F1652 MSDS PDF |
|---|---|
| Info Sheet | F1652 Info Sheet PDF |
Moore RA, Derry S, McQuay HJ. Single dose oral fenbufen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007547. PMID: 19821427.
Costa D, Moutinho L, Lima JL, et al. Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol Pharm Bull. 2006 Aug;29(8):1659-70. PMID: 16880623.
