FlufenamicacidisaCOX-inhibitingnon-steroidalanti-inflammatorydrug(NSAID)thatexhibitsneuromodulatory,anti-inflammatory,antipyretic,analgesic,andantiepileptic/anticonvulsantactivities.Flufenamicinhibitsvoltage-gatedNa+channels,transientreceptorpotentialcanonical3(TRPC3)channels,andtransientreceptorpotentialmelastatin-like2(TRPM2)channelsandpotentiatesTREK1(KCNK2)channelactivity.Invitro,flufenamicaciddecreasesglutamatergicexcitatoryactivityandneuronalexcitABIlity.
| CasNo. | 530-78-9 |
|---|---|
| Purity | ≥97% |
| Formula | C14H10F3NO2 |
| FormulaWt. | 281.23 |
| ChemicalName | 2-[[3-(Trifluoromethyl)phenyl]amino]benzoicacid |
| IUPACName | 2-[3-(trifluoromethyl)anilino]benzoicacid |
| Synonym | Achless;Ansatin;Arlef;Fullsafe;Parlef;Sastridex;Tecramine |
| MeltingPoint | 125°C |
| Solubility | Solublein4partsofethanol.SolubleinDMSOto100mMandinethanolto100mM |
| Appearance | Whitetopaleyellowpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F4483MSDSPDF |
|---|---|
| InfoSheet | F4483InfoSheetPDF |
| Brochures | TRPChannelModulatorFlyer |
XieYF,ZhouF.TRPC3channelmediatesexcitationofstriatalcholinergicinterneurons.NeurolSci.2014May21.[Epubaheadofprint].PMID:24844791.
VealeEL,Al-MoubarakE,BajariaN,etal.InfluenceoftheNterminusonthebiophysicalpropertiesandpharmacologyofTREK1potassiumchannels.MolPharmacol.2014May;85(5):671-81.PMID:24509840.
NazıroğluM,ÖzgülC,ÇelikÖ,etal.AminoethoxydiphenylborateandflufenamicacidinhibitCa2+influxthroughTRPM2channelsinratdorsalrootganglionneuronsactivatedbyADP-riboseandrotenone.JMembrBiol.2011May;241(2):69-75.PMID:21509529.
YauHJ,BaranauskasG,MartinaM.Flufenamicaciddecreasesneuronalexcitabilitythroughmodulationofvoltage-gatedsodiumchannelgating.JPhysiol.2010Oct15;588(Pt20):3869-82.PMID:20724367.
FernándezM,Lao-PeregrínC,MartínED.Flufenamicacidsuppressesepileptiformactivityinhippocampusbyreducingexcitatorysynaptictransmissionandneuronalexcitability.Epilepsia.2010Mar;51(3):384-90.PMID:19732136.
