Fluphenazine is a typical piperazine antipsychotic that is clinically used to treat schizophrenia, bipolar disorder, and dementia. Fluphenazine acts as an antagonist at D2 receptors. Fluphenazine also exhibits arrhythmogenic activity, increasing action potential duration and inducing QT prolongation by decreasing current amplitude of human ether-related-a-go-go (hERG) K+ channels. This compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA).
| Cas No. | 146-56-5 |
|---|---|
| Purity | ≥97% |
| Formula | C22H26F3N3OS 2HCl |
| Formula Wt. | 510.44 |
| Chemical Name | 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)- |
| IUPAC Name | 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride |
| Synonym | Dapotum; Elinol; Fluorfenazine; Fluorophenazine; Pacinol; Moditen. |
| Solubility | Soluble in water (>100 mg/L), ethanol (149 mg/mL) |
| Appearance | White or near-white crystalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | F4584 MSDS PDF |
|---|---|
| Info Sheet | F4584 Info Sheet PDF |
Hong HK, Lee BH, Park MH, et al. Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration. Eur J Pharmacol. 2013 Feb 28;702(1-3):165-73. PMID: 23395964.
Pickar D, Owen RR, Litman RE, et al. Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine. Arch Gen Psychiatry. 1992 May;49(5):345-53. PMID: 1375019.
