Fluphenazineisatypicalpiperazineantipsychoticthatisclinicallyusedtotreatschizophrenia,bipolardisorder,anddementia.FluphenazineactsasanantagoNISTatD2receptors.Fluphenazinealsoexhibitsarrhythmogenicactivity,increasingactionpotentialdurationandinducingQTprolongationbydecreasingcurrentamplitudeofhumanether-related-a-go-go(hERG)K+channels.Thiscompoundactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
| CasNo. | 146-56-5 |
|---|---|
| Purity | ≥97% |
| Formula | C22H26F3N3OS2HCl |
| FormulaWt. | 510.44 |
| ChemicalName | 1-Piperazineethanol,4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)- |
| IUPACName | 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride |
| Synonym | Dapotum;Elinol;Fluorfenazine;Fluorophenazine;Pacinol;Moditen. |
| Solubility | Solubleinwater(>100mg/L),ethanol(149mg/mL) |
| Appearance | Whiteornear-whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F4584MSDSPDF |
|---|---|
| InfoSheet | F4584InfoSheetPDF |
HongHK,LeeBH,ParkMH,etal.BlockofhERGK+channelandprolongationofactionpotentialdurationbyfluphenazineatsubmicromolarconcentration.EurJPharmacol.2013Feb28;702(1-3):165-73.PMID:23395964.
PickarD,OwenRR,LitmanRE,etal.ClinicalandBIOLOGicresponsetoclozapineinpatientswithschizophrenia.Crossovercomparisonwithfluphenazine.ArchGenPsychiatry.1992May;49(5):345-53.PMID:1375019.
