Ondansetronexhibitsantiemetic,antidepressant,andanxiolyticactivities;itisanantagoNISTat5-HT3receptors.Throughdownstreameffectson5-HTsignaling,ondansetrondecreasesimmobilitytimeintheforcedswimtestandincreasesopenarmentriesintheelevatedplusmaze.
| CasNo. | 103639-04-9 |
|---|---|
| Purity | ≥98% |
| Formula | C18H19N3O•HCl•2H2O |
| FormulaWt. | 365.86 |
| ChemicalName | 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-onehydrochloridedihydrate |
| IUPACName | 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride |
| Synonym | Zofran;Zophren |
| MeltingPoint | 178.5-179.5°C |
| Solubility | Solubleinwater. |
| Appearance | Whitecrystalpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | O5212MSDSPDF |
|---|---|
| InfoSheet | O5212InfoSheetPDF |
KurheY,RadhakrishnanM,GuptaD.Ondansetronattenuatesdepressionco-morbidwithobesityinobesemicesubjectedtochronicunpredictablemildstress;anapproachusingbehavioralbatterytests.MetabBrainDis.2014Jun27.[Epubaheadofprint].PMID:24964970.
RojasC,RajeM,TsukamotoT,etal.Molecularmechanismsof5-HT(3)andNK(1)receptorantagonistsinpreventionofemesis.EurJPharmacol.2014Jan5;722:26-37.PMID:24184669.
