Ondansetron exhibits antiemetic, antidepressant, and anxiolytic activities; it is an antagonist at 5-HT3 receptors. Through downstream effects on 5-HT signaling, ondansetron decreases immobility time in the forced swim test and increases open arm entries in the elevated plus maze.
| Cas No. | 103639-04-9 |
|---|---|
| Purity | ≥98% |
| Formula | C18H19N3O • HCl • 2H2O |
| Formula Wt. | 365.86 |
| Chemical Name | 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H- imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride dihydrate |
| IUPAC Name | 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride |
| Synonym | Zofran; Zophren |
| Melting Point | 178.5-179.5°C |
| Solubility | Soluble in water. |
| Appearance | White crystal powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | O5212 MSDS PDF |
|---|---|
| Info Sheet | O5212 Info Sheet PDF |
Kurhe Y, Radhakrishnan M, Gupta D. Ondansetron attenuates depression co-morbid with obesity in obese mice subjected to chronic unpredictable mild stress; an approach using behavioral battery tests. Metab Brain Dis. 2014 Jun 27. [Epub ahead of print]. PMID: 24964970.
Rojas C, Raje M, Tsukamoto T, et al. Molecular mechanisms of 5-HT(3) and NK(1) receptor antagonists in prevention of emesis. Eur J Pharmacol. 2014 Jan 5;722:26-37. PMID: 24184669.
