Description
Oxcarbazepine(OX)isanantiepileptic/anticonvulsantcommonlyusedtotreatepilepsy,butalsoexhibitsactivityasatreatmentformooddisordersandneuropathicpainaswell.AdmiNISTrationofoxcarbazepineleadstoareversIBLereductionincurrentamplitudefromvoltage-gatedNa+channelsandmaysuppresscurrentamplitudeofdelayedrectifyingK+channels;thisreducestheamplitudeofactionpotentialsandprolongstheirduration.ThiscompoundalsoinhibitsNa+channel-dependentGlureleaseandproducesamoderateopenchannelblockonnicotinicacetylcholinereceptors(nAChRs),preventingdeactivation.Interestingly,oxcarbazepinemayhavepotentialasatreatmentforsubstanceabusedisorders,asitismoderatelyeffectiveasarelapsepreventiontreatmentinaclinicaltrialofrecentlyabstinentalcohol-dependentsubjects.
References
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