Description
P7C3isanaminopropylcarbazolethatdisplaysneuroprotective,antidepressant,andcognitionenhancingactivities,particularlyinmodelsofParkinson’sdiseaseandamyotrophiclateralsclerosis(ALS).P7C3promotesneurogenesisinvivointhehippocampaldentategyrus,preventingneuronapoptosisinnewbornmice,andalsopreventsneurondeathandcognitivedeclineinagedmice.P7C3rescuesTGF-βligandmutation-inducedretinalapoptosisinvivo.InC.elegansmodels,thiscompoundinhibitsMPP+-mediateddeathofdopaminergicneurons.Also,whengivenpriortoexpectedsymptomonset,P7C3delaysdiseaseprogressioninanimalmodelsofALS.
References
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