Description
MoclobemideisareversIBLeinhibitorofMAO-Athatexhibitsantidepressant,anti-inflammatory,antinociceptive,andneuromodulatoryactivities.MoclobemidedecreasesimmobilitytimeinanimalsundergoingtheforcedswimtestandsuppressesLPS-inducedincreasesinIL-1βandTNF-αexpressioninglialcells.Additionally,moclobemideincreaseslatencytimeinanimalmodelsofthermalpainthroughanα2-adrenergicreceptor-mediatedpathway.Moclobemidealsoinduceshippocampalneurogenesis,upregulatingProgenitorcellproliferationandexpressionofBDNFinvitro.
References
BieleckaAM,Paul-SamojednyM,ObuchowiczE.Moclobemideexertsanti-inflammatoryeffectinlipopolysaccharide-activatedprimarymixedglialcellculture.NaunynSchmiedebergsArchPharmacol.2010Dec;382(5-6):409-17.PMID:20811738.
LiYF,ZhangYZ,LiuYQ,etal.Moclobemideup-regulatesproliferationofhippocampalprogenitorcellsinchronicallystressedmice.ActaPharmacolSin.2004Nov;25(11):1408-12.PMID:15525460.
SchreiberS,GetslevV,WeizmanA,etal.Theantinociceptiveeffectofmoclobemideinmiceismediatedbynoradrenergicpathways.NeurosciLett.1998Sep11;253(3):183-6.PMID:9792241.
FerigoloM,BarrosHM,MarquardtAR,etal.Comparisonofbehavioraleffectsofmoclobemideanddeprenylduringforcedswimming.PharmacolBiochemBehav.1998Jun;60(2):431-7.PMID:9632226.
