MontelukastisanantagoNISTatcysteinylleukotriene1(CysLT1)receptors;itexhibitsanti-allergic,anti-asthma,anti-inflammatory,analgesic,anti-tussive,andbronchodilatoryactivities.Montelukastisclinicallyusedtotreatallergicrhinitisandasthma,althoughitalsoattenuatescoughanddecreaseseosinophilinfiltration.Montelukastdecreasesexpressionofp38MAPK,NF-κB,IL-1β,IL-6,andTNF-αandinhibitsactivationofmicroglia,attenuatingneuropathicpaininanimalmodelsofchronicconstrictiveinjury(CCI).
| CasNo. | 151767-02-1 |
|---|---|
| Purity | ≥98% |
| Formula | C35H35ClNO3SNa |
| FormulaWt. | 608.17 |
| ChemicalName | 1-((((1R)-1-(3-((1E)-2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-Cyclopropaneaceticacid,monosodiumsalt |
| IUPACName | sodium;2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate |
| Synonym | Singulair |
| Solubility | Solubleinethanol,DMSO. |
| Appearance | Off-whitetopaleyellowhygroscopicpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | M5756MSDSPDF |
|---|---|
| InfoSheet | M5756InfoSheetPDF |
ZhouC,ShiX,HuangH,etal.MontelukastAttenuatesNeuropathicPainThroughInhibitingp38Mitogen-ActivatedProteinKinaseandNuclearFactor-KappaBinaRatModelofChronicConstrictionInjury.AnesthAnalg.2014May;118(5):1090-6.PMID:24686047.
NiimiA.Cough,asthma,andcysteinyl-leukotrienes.PulmPharmacolTher.2013Oct;26(5):514-9.PMID:23774534.
