Necrostatin-1isaninhibitorofreceptorinteractingprotein1(RIP1),preventingnecroptosis,aprogrammedcelldeath.Necrostatin-1exhibitsnephroprotective,neuroprotective,andcytoprotectiveactivities.Inanimalmodelsofchronickidneydisease,necrostatin-1improvesrenalfunctionandpathologybypreventinglossofrenalcells.Necrostatin-1alsopreventsdeathofhippocampalneuronsinanimalmodelsofcerebralischemia.
| CasNo. | 4311-88-0 |
|---|---|
| Purity | ≥99% |
| Formula | C13H13N3OS |
| FormulaWt. | 259.33 |
| IUPACName | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Appearance | Off-whitetoyellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | N1610InfoSheetPDF |
|---|
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YinB,XuY,WeiRL,etal.Inhibitionofreceptor-interactingprotein3upregulationandnucleartranslocationinvolvedinNecrostatin-1protectionagainsthippocampalneuronalprogrammednecrosisinducedbyischemia/reperfusioninjury.BrainRes.2015Jun3;1609:63-71.PMID:25801119.
SteinwascherS,NuguesAL,SchoeNEBergerH,etal.IdentificationofanovelsynergisticinductionofcelldeathbySmacmimeticandHDACinhibitorsinacutemyeloidleukemiacells.CancerLett.2015May28.[Epubaheadofprint].PMID:26028172.
