Description
Norepinephrine is a hormone and neurotransmitter that modulates sympathetic nervous system activity and plays a role in modulating reward, reinforcement, feeding, and other behaviors. Norepinephrine exhibits vasoconstrictive, pro-angiogenic, and thermoregulatory activities. Norepinephrine is clinically used to treat cardiac arrest, severe hypotension, and shock. This compound acts as an agonist at α- and β-adrenergic receptors, inducing vascular vasoconstriction, decreasing blood flow, and increasing blood pressure. In vitro, norepinephrine increases expression of VEGF and stimulates choroidal neovascularization. This compound also decreases code body temperature.
References
Lavine JA, Sang Y, Wang S, et al. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013 Mar;131(3):376-82. PMID: 23303344.
Liang MJ, He LC, Yang GD. Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong. Life Sci. 2005 Nov 26;78(2):128-33. PMID: 16154159.
Weiser M, Hilz MJ, Bronfin L, et al. Assessing microcirculation in familial dysautonomia by laser Doppler flowmeter. Clin Auton Res. 1998 Feb;8(1):13-23. PMID: 9532416.
Laudenslager ML. The influence of hypothalamic temperature on some thermoregulatory effects of hypothalamic injections of norepinephrine. Pharmacol Biochem Behav. 1976 Dec;5(6):713-6. PMID: 828727.
