OlomoucineisapurinederivativethatinhibitsCDKsandexhibitsanti-inflammatory,neuroprotective,andanticanceractivities.Inmacrophages,olomoucinedecreaseslevelsofNOandiNOSandsuppressesactivationofNF-κB.Inleukemiacells,olomoucinealterscellcycleprogressionandinhibitsproliferation.Additionally,thiscompoundpreventscathepsinLtranslocationandtheinductionofautophagyinneurons,protectingagainst6-OHDA-inducedtoxicity.
| CasNo. | 101622-51-9 |
|---|---|
| Purity | ≥98% |
| Formula | C15H18N6O |
| FormulaWt. | 298.34 |
| ChemicalName | 6-Benylamino-2-(2-hydroxyethylamino)-9-methyl-purine |
| IUPACName | 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol |
| Synonym | 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine |
| MeltingPoint | 120-130°C |
| Solubility | SolubleinDMSOormethanol. |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | O4556MSDSPDF |
|---|---|
| InfoSheet | O4556InfoSheetPDF |
WandlS,Wesierska-GadekJ.Isolomoucine,aweakCDK2inhibitor,abletoinduceapoptosisincancercells?AnnNYAcadSci.2009Aug;1171:242-9.PMID:19723061.
FeiXF,QinZH,XiangB,etal.OlomoucineinhibitscathepsinLnucleartranslocation,activatesautophagyandattenuatestoxicityof6-hydroxydopamine.BrainRes.2009Apr6;1264:85-97.PMID:19368812.
