Gastric inhibitory peptide (GIP) is an endogenous peptide hormone analog of somatostatin that is involved in insulin signaling. GIP is secreted in response to food intake and enhances insulin secretion from pancreatic β-cells. GIP also increases plasma membrane translocation of GLUT4 in a cAMP/PKA/PI3K-dependent manner. GIP binds and activates GIP receptors.
| Cas No. | 100040-31-1 |
|---|---|
| Purity | ≥95% |
| Formula | C226H338N60O66S |
| Formula Wt. | 4983.64 |
| Synonym | GIP |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G0175 Info Sheet PDF |
|---|
Mohammad S, Ramos LS, Buck J, et al. Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. J Biol Chem. 2011 Dec 16;286(50):43062-70. PMID: 22027830.
Adrian TE, Barnes AJ, Long RG, et al. The effect of somatostatin analogs on secretion of growth, pancreatic, and gastrointestinal hormones in man. J Clin Endocrinol Metab. 1981 Oct;53(4):675-81. PMID: 6116721.
