Katacalcinisapolypeptideencodedbythecalc-1genethatisalsoknownascrustaceancardioactivepeptide(CCAPorCCP1).Katacalcinexhibitsimmunomodulatoryactivity.KatacalcinactivatesPKAanddecreasesintracellularCa2+levels,inducingmigrationofCD14+peripheralbloodmononuclearcellsanddeactivatingchemotaxis.KatacalcinmaybeusedasabioMarkerformedullarythyroidtumors.Additionally,thispeptidemayplayaroleinsignalingcascadeelicitedbytreatmentsformooddisorders,suchasantipsychoticmedications.
| CasNo. | 85916-47-8 |
|---|---|
| Purity | ≥95% |
| Formula | C97H154N34O36S2 |
| FormulaWt. | 2436.64 |
| Synonym | CCAP,CCPI,Calcitonincarboxyl-terminalflankingpeptide |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K0276InfoSheetPDF |
|---|
KaneiderNC,EggerP,WiedermannFJ,etal.Involvementofcyclicadenosinemonophosphate-dependentproteinkinaseAandpertussistoxin-sensitiveGproteinsinthemigratoryresponseofhumanCD14+mononuclearcellstokatacalcin.JBoneMinerRes.2002Oct;17(10):1872-82.PMID:12369791.
AngelucciF,GruberSH,MathéAA.Apilotstudyofratbrainregionaldistributionofcalcitonin,katacalcinandcalcitoningene-relatedpeptidebeforeandafterantipsychotictreatment.Neuropeptides.2001Oct-Dec;35(5-6):285-91.PMID:12030813.
BlindE,RaueF,KlaiberT,etal.EvaluationofsensitivePDN-21(katacalcin)determinationastumormarkerinmedullarythyroidcarcinoma.JEndocrinolInvest.1992Feb;15(2):93-8.PMID:1569295.
