NaltribenisanantagoNISTatδ2-opioidreceptors(D2ORs).Naltribeninducesanxietyinanimalmodelsundergoinglight/darktestsandopenfieldactivitymeasurements;italsoinhibitsopioid-inducedreinforcementinconditionedplacepreferenceassays.Additionally,naltribeninhibitsantinociceptiveactivitiesregulatedbyδORsinthespinalcord.
| Purity | ≥95% |
|---|---|
| Formula | C50H65N11O11S2 |
| FormulaWt. | 1060.29 |
| Synonym | NTB |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | N7604InfoSheetPDF |
|---|
SugiyamaA,NagaseH,OkaJI,etal.DOR2-selectivebutnotDOR1-selectiveantagonistabolishesanxiolytic-likeeffectsoftheδopioidreceptoragonistKNT-127.Neuropharmacology.2013Dec12;79C:314-320.PMID:24333676.
BillaSK,XiaY,MorónJA.Disruptionofmorphine-conditionedplacepreferencebyadelta2-opioidreceptorantagonist:studyofmu-opioidanddelta-opioidreceptorexpressionatthesynapse.EurJNeurosci.2010Aug;32(4):625-31.PMID:20626460.
TsengLF,CollinsKA,PortoghesePS.Spinaldelta2butnotdelta1opioidreceptorsareinvolvedinintracerebroventricularbeta-endorphin-inducedantinociceptioninthemouse.LifeSci.1993;52(19):PL211-5.PMID:8387138.
