Neuropeptide F (NPF) is a neuropeptide Y-like ortholog found in insects and gastropods. NPF modulates sleep activity, suppressing signaling of wake-promoting ventrolateral clock neurons. NPF also modulates cAMP/PKA/CREB signaling in animal models. Additionally, NPF plays a role in learning, stress responses, feeding, and courtship behavior; in male locusts, NPF increases the weight of the testes and seminal vesicles.
| Purity | ≥95% |
|---|---|
| Formula | C51H80N15O19P |
| Formula Wt. | 768.79 |
| Synonym | NPF |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | N6020 Info Sheet PDF |
|---|
Shang Y, Donelson NC, Vecsey CG, et al. Short neuropeptide F is a sleep-promoting inhibitory modulator. Neuron. 2013 Oct 2;80(1):171-83. PMID: 24094110.
Chen W, Shi W, Li L, et al. Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster. Insect Biochem Mol Biol. 2013 Sep;43(9):809-19. PMID: 23796436.
Van Wielendaele P, Wynant N, Dillen S, et al. In vivo effect of Neuropeptide F on ecdysteroidogenesis in adult female desert locusts (Schistocerca gregaria). J Insect Physiol. 2013 Jun;59(6):624-30. PMID: 23524065.
Van Wielendaele P, Wynant N, Dillen S, et al. Neuropeptide F regulates male reproductive processes in the desert locust, Schistocerca gregaria. Insect Biochem Mol Biol. 2013 Mar;43(3):252-9. PMID: 23295785.
Leung PS, Shaw C, Johnston CF, et al. Immunocytochemical distribution of neuropeptide F (NPF) in the gastropod mollusc, Helix aspersa, and in several other invertebrates. Cell Tissue Res. 1994 Feb;275(2):383-93. PMID: 8111844.
