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商品详细LKT/M35/M0035/0.5 mg
LKT/M35/M0035/0.5 mg
LKT/M35/M0035/0.5 mg
商品编号: M0035-0.5mg
品牌: lktlabs
市场价: ¥2200.00
美元价: 1320.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽
公司分类: peptides
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

M35 is a peptide antagonist at galanin receptors that exhibits antidepressant and insulin-modulating activities. In the forced swim test, M35 decreases immobility time. M35 displays neuroprotective and cognition enhancing activities as well, improving acquisition time, decreasing the number of failed trials, and shortening escape latency in rodents undergoing the forced swim test, an animal model of spatial learning. M35 also suppresses pancreatitis-induced plasma hyperenzymemia and decreases myeloperoxidase activity, decreasing necrosis. Additionally, M35 decreases glucose uptake, PPARα expression, and membrane GLUT4 levels, attenuating insulin sensitivity in other animal models.

Product Info

Cas No.

142846-71-7

Purity

≥95%

Formula

C107H153N27O26

Formula Wt.

2233.58

Synonym

Galanin-(1-13)-bradykinin-(2-9)-amide

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

M0035 Info Sheet PDF

References

Bu L, Liu Z, Zou J, et al. Blocking central galanin receptors attenuates insulin sensitivity in myocytes of diabetic trained rats. J Neurosci Res. 2013 Jul;91(7):971-7. PMID: 23653288.

Bhandari M, Kawamoto M, Thomas AC, et al. Galanin receptor antagonist m35 but not m40 or c7 ameliorates cerulein-induced acute pancreatitis in mice. Pancreatology. 2010;10(6):682-8. PMID: 21242707.

Jiang L, Shi M, Guo L, et al. Effect of M35, a neuropeptide galanin antagonist on glucose uptake translated by glucose transporter 4 in trained rat skeletal muscle. Neurosci Lett. 2009 Dec 25;467(2):178-81. PMID: 19835935.

Kuteeva E, Wardi T, Hökfelt T, et al. Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat. Eur Neuropsychopharmacol. 2007 Jan;17(1):64-9. PMID: 16624535.

Ogren SO, Hökfelt T, Kask K, et al. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 1992 Nov;51(1):1-5. PMID: 1281521.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂